Xavier Musketeers (25-4, 13-4)
Creighton Bluejays (18-12, 9-8)
Get on the offensive glass- Seven of the Bluejays 12 losses have come when they allow opponents to get over that 25% season average they allow on the glass. While that doesn't seem terribly impressive, the Jays are only 6-6 when opponents get 29% of their misses. The more chances that Creighton allows on the offensive glass, the more likely they are to lose.
Don't go 1-21 again- Xavier's defense wasn't actually that bad against the Bluejays last time. Creighton didn't even manage a point per possession. Xavier's offense, on the other hand, was an abomination. While X just kept missing, the Jays just backed inside and made Jalems Farrnolds work that much harder to score. Creighton's defense will look world beating again if Xavier doesn't knock down some outside shots.
Don't get hurt- Honestly, the result of this game only matters in that no one wants to watch a loss on Senior Day or go into the conference tournament on a two game loser. What is much more pressing is that Xavier goes into the postseason with all cylinders firing. If that means deploying a walk-on to follow Ed around and make sure he doesn't land on anything too hard, so be it. A win here solidifies Xavier as a two seed, losing a key player is the nightmare scenario.