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Keys to the game:
-Keep the crowd out of it. There's no question Xavier is the better team here, but there's also no question that weird things can happen on the road in conference play. Better teams lose to worse teams all the time, especially when the worse team is hosting and can really get a boost from a good environment. If Xavier can come out early and remove hope from the fans, St. John's won't have an arena full of 5,602 (assuming they sell out) New Yorkers urging them on.
-Crash the glass. About the only thing the Johnnies do well on defense is block shots. One natural consequence of chasing blocks, though, is surrendering defensive rebounding position. Sima et al. are going to return their share of attempts, but the shots that do reach the rim should have a pretty good chance of bouncing to Muskies if Xavier commits bodies to the boards.
-Take care of business. Remember how Xavier sleepwalked through the NKU game? The opposite of that. This should be the kind of game where Myles ends up watching the last five minutes and Tim Stainbrook tries to reprise his Mutumbo act from the Butler game. Getting to that point requires doing the work to build an insurmountable lead; I suspect X is mature enough to do just that.